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Other examples of the modular organization
of plasmids include the frequent close association of plasmid replication and
maintenance cassettes and the clustering of genes for conjugation functions in
specific plasmid regions. Over time, common control circuits have developed in
some plasmids that coordinate these core activities of replication,
maintenance, and transfer (74). The continued molecular dissection of plasmids, both at
the genomic level and in finer detail concerning the molecular function of specific
systems, will undoubtedly prove as exciting and informative in the immediate
future as the analysis of these versatile elements has proven in the last half
century.
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